Publications
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Garren, H., W.H. Robinson, E. Krasulova´, E Havrdova´, C. Nadj, K. Selmaj, J. Losy, I. Nadj, E.-W. Radue, B.A. Kidd, J. Gianettoni, K. Tersini, P.J. Utz, F. Valone, L. Steinman, and the BHT-3009 Study Group, 2008. Phase 2 Trial of a DNA Vaccine Encoding Myelin Basic Protein for Multiple Sclerosis. Ann. Neurol. 63:611-620. Download PDF.
Thibault, D.L., A.D. Chu,1 K.L. Graham, I. Balboni, L.Y. Lee, c. Kohlmoos, A. Landrigan, J.P. Higgins, R. Tibshirani, P.J. Utz, 2008. IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J. Clinical Investigation. Epub 13 March 2008. For reprints, please email .
Bar-Or, A., Vollmer, T., Antel, J., Arnold, D.L., Bodner, C.A., Campagnolo, D., Gianettoni, J., Jalili, F.,Kachuck, N., Lapierre, Y., Niino, M., Oger, J., Price, M., Rhodes, S., Robinson, W.H., Shi, F.-D., Utz, P.J., Valone, F., Weiner, L., Steinman, L., Garren, H. Induction of Antigen-Specific Tolerance in Multiple Sclerosis After Immunization With DNA Encoding Myelin Basic Protein in a Randomized, Placebo-Controlled Phase 1/2 Trial. Arch. Neurol. 2007;64:E1-E9. PDF.
Chan, S.M., A.P. Weng, R. Tibshirani, J.C. Aster, P.J. Utz. Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood. 2007, 110:278-286. PDF
Sharpe, V., P.J. Utz. Technology Insight: can autoantibody profiling
improve clinical practice? Nature Clinical Practice. 2007,
3:96-103. PDF
Shi X., I. Kachirskaia, K.L. Walter, J.H. Kuo, A. Lake, F. Davrazou, S.M. Chan, D.G. Martin, I.M. Fingerman, S.D. Briggs, L.Howe, P.J. Utz, T.G. Kutateladze, A.A. Lugovskoy, M.T. Bedford, O. Gozani O. Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. Journl of Biological Chemistry 2007, 282:2450-5. Epub 2006 Dec 1.
Graham, K.L., M. Vaysberg, A. Kuo and P. J. Utz Autoantigen arrays for multiplex analysis of antibody isotypes. Proteomics 2006, 6:5720–5724. For reprints, please email .
Sekine H., K. L. Graham, S. Zhao, M.K. Elliott, P. Ruiz, L. Morel, V. M. Holers, P.J. Utz and G. S. Gilkeson. Role of MHC-linked genes in autoantigen selection and renal disease in a murine model of SLE. J. Immunol. 2006. 177:7423-7434. PDF
Kattah M.G., G.R. Alemi, D.L. Thibault and P.J. Utz. A novel two-color fab labeling method for autoantigen protein microarrays. Nature Methods. 2006.3:745-751. PDF
Chan SM, J. Olsen, P.J. Utz. Single-cell analysis of siRNA-mediated gene silencing using multiparameter flow cytometry. Cytometry. 2006. 69A(2):59-65. PDF
Balboni I., S.M. Chan, M. Kattah, J.D. Tenenbaum, A.J. Butte and P.J. Utz. Multiplexed protein array platforms for analysis of autoimmune diseases. In: Annual Review of Immunology, W. Paul, C.G. Fathman, L.H. Glimcher (Eds), pps. 391-418, Vol. 24, 2006. PDF
Utz, P.J. Protein arrays for studying blood cells and their secreted products. Immunol. Rev. 2005. 204:264-282. PDF
Chan S.M. and P.J. Utz. The challenge of analyzing the proteome in humans with autoimmune diseases. Ann. NY Acad. Sci. 2005. 1062:61-68. PDF
Ida I., P.J. Utz, P. Anderson and K. Eguchi. Granzyme B and natural killer (NK) death. Mod. Rheumtol. 2005. 15:315-322. PDF
Utz, P.J. Protein arrays for studying blood cells and their secreted products. Immunol. Rev. 2005. 204:264-282. PDF
Huang, M. H.Ida, M. Kamachi, N. Iwanaga, Y. Izumi, F. Tanaka, K. Aratake, K. Arima, M. Tamai, A. Hida, H. Nakamura, T. Origuchi, A. Kawakami, N. Ogawa, S. Sugai, P.J. Utz and K. Eguchi. Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren’s Syndrome. Clin. Exp. Immunol. 2005. 42:148-154. PDF
Steinman L, Utz PJ, Robinson WH. Suppression of autoimmunity via microbial mimics of altered peptide ligands. Curr Top Microbiol Immunol. 2005;296:55-63. PDF
Graham K.L., D. L. Thibault, M. Kamachi, S. Zhao, J. Steinman, L. Okeke, P. N. Kao and P.J. Utz. Granzyme B is dispensable for immunological tolerance to self in a murine model of systemic lupus erythematosus. Arth. Rheum. 2005. 52:1684-1693. PDF
Hueber W, Kidd BA, Tomooka BH, Lee BJ, Bruce B, Fries JF, Sonderstrup G, Monach P, Drijfhout JW, van Venrooij WJ, Utz PJ, Genovese MC, Robinson WH. Antigen microarray profiling of autoantibodies in rheumatoid arthritis. Arthritis Rheum. 2005, 52(9):2645-55. PDF
Graham K.L. and P.J. Utz. Sources of autoantigens in systemtic lupus erythematosus.
Curr. Opin. Rheumatol. 2005. 17:513-517. PDF
Huston D.P., C.G. Fathman and P.J. Utz. Fostering interdisciplinary immunology. Clin. Immunol. 2005. 115:1-2.
Fathman, C.G., L. Soares, S.M. Chan and P.J. Utz. An array of possibilities for the study of autoimmunity. Nature 2005. 435:605-611. PDF
Chan, S.M., J. Ermann, L. SU, C.G. Fathman and P.J. Utz. Protein Microarrays for Multiplex Analysis of Signal Transdaucton Pathways. Nature Medicine. 2004. 10:1390-1396. Supporting Documents: Raw Data (Excel Format), Antibody Sources (Excel), Lysis Buffer Recipe (Word Format), Reverse Phase Microarray Protocol (Word Format). PDF
Utz P.J. Hot technologies in immunology. Clin. Immunol. 2004. 111:153-4. PDF
Utz P.J., M.C. Genovese, W.H. Robinson. Unlocking the "PAD" lock on rheumatoid arthritis. Ann. Rheum. Dis. 2004. Ann. Rheum. Dis. 4:330-332. PDF
Chung L. and P.J. Utz. Autoantibodies in scleroderma: Direct pathogenicity and phenotypic associations. Curr. Rheum. Reports 2004. 6:156-163. PDF
Utz P.J., L. Steinman and W.H. Robinson. Protein microarrays for analysis of immune responses in animals and humans. In: Protein Micoarrays, pp 365-376, Edited by Michael Schena. 2004. Jones and Bartlett, Sudbury, MA.
Hueber, W., D. Zeng, O. Sharpe, W.H. Robinson, S. Strober and P.J. Utz. Characterization of novel antigens recognized by serum autoantibodies from anti-CD1 TCR-transgenic lupus mice. Eur. J. Immunol. 2004. 34:1654–1662. PDF
Utz, P.J. Multiplexed assays for identification of biomarkers and surrogate markers in systemic lupus erythematosus. Lupus. 2004. 13:304-11. PDF
Graham, K.L., K.E. Gustin, C. Rivera, N.M. Kuyumcu-Martinez, S.S. Choe, R.E. Lloyd P. Sarnow and P.J. Utz. Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection. J. Virol 2004. 78:6313-21. PDF
Hueber, W., D. Zeng, S. Strober, P.J. Utz. Interferon-alpha-inducaible proteins are novel antigens in murine lupus. Arthritis and Rheumitism. 2004. 50:3239-3249. PDF
Su, L., R.J. Creusot, E.Gallo, S.M. Chan, P.J. Utz, C.G. Fathman and J. Ermann. Murine CD4+CD25+-regulatory T-cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene. J. Immuol. 2004. 173:4994-5001. PDF
Utz., P.J. and S. Chan. Autoantibodies profiling and lymphocyte characterization using autoantigen and lysate arrays. In Pathogenic and Diagnostic Relevance of Autoantibodies. K. Conrad, R. L. Humbel, M. Meurer, Y. Shoenfeld, E.M. Trans (Eds.) 7th Dresden, Sept. 1-4 2004, 2004.
Graham KL, Robinson WH, Steinman L, Utz PJ. High-throughput methods for measuring autoantibodies in systemic lupus erythematosus and other autoimmune diseases. Autoimmunity. 2004, 37(4):269-72. Review. PDF
Hueber, W. and Utz, P.J. "Modifications of RNA During Apoptosis." In, Apoptosis and Autoimmunity, Edited by Joachim Kalden and Martin Herrmann. 2003. 299-315.
Herr A.E., J.I. Molho, K.A. Drouvalakis, J.C. Mikkelsen, P.J. Utz, J.G. Santiago and T.W. Kenny. On-Chip Coupling of Isoelectric Focusing and Free Solution Electrophoresis for Multi-Dimensional Separations. Anal. Chem. 2003. 75:1180-1187.
Chen R.J., S. Bangsaruntip, K. A. Drouvalakis, N.W.S. Kam, M. Shim, Y. Li, W. Kim, P.J. Utz and H. Dai. Noncovalent functionalization of carbon nanotubes for highly specific electronic sensors. Proc. Natl. Acad. Sci. USA 2003. 100:4984-4989. PDF
Robinson W.H., P. Fontoura, B.J. Lee, H.E. Neuman de Vegvar, J. Tom, R. Pedotti, C.D. DiGennaro, D.J. Mitchell, D. Fong, P.P-K. Ho, P. Ruiz, E. Maverakis, D.B. Stevens, C.C.A. bernard, R. Martin, V.K. Kuchroo, J.M. van Noort, C.P. Genain, S. Amor, T. Olsson, P.J. Utz*, H. Garren* and L. Steinman*. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nature Biotechnol. 2003. 21:1033-1039. *All three authors contributed equally to this paper. PDF.
Neuman de Vegvar H.E., R.R. Amara, L. Steinman, P.J. Utz, H.L. Robinson and W.H. Robinson. Microarray profiling of antibody responses against Simian-Human immunodeficiency virus: Postchallenge of host histocompatibility type and vaccine regimen. J. Virol. 2003. 77:11125-11138. PDF
Thibault, Donna L and Paul J Utz. Interpreting interest in interferon-alpha. Arthritis Res. and Res. Ther. 2003. 5(5):246-248. PDF
Hueber W, Utz PJ, Robinson WH. Autoantibodies in early arthritis: advances in diagnosis and prognostication. Clin Exp Rheumatol. 2003, 21(5 Suppl 21): S59-64. Review. PDF
Robinson WH, Utz PJ, Steinman L. Genomic and proteomic analysis of multiple sclerosis. Opinion. Curr Opin Immunol. 2003, 15(6):660-7. PDF
Robinson WH, Steinman L, Utz PJ. Protein arrays for autoantibody profiling and fine-specificity mapping. Proteomics. 2003, 3(11):2077-84. PDF
Robinson WH, Steinman L, Utz PJ. Protein and peptide array analysis of autoimmune disease. Biotechniques. 2002, Suppl:66-9. Review. PDF
Hueber W, Utz PJ, Steinman L, Robinson WH. Autoantibody profiling for the study and treatment of autoimmune disease. Arthritis Res. 2002, 4(5):290-5. Review. PDF
Kamachi M. T.M. Le, S. Kim, M.E. Geiger, P. Anderson, P. and P.J. Utz. Human Autoimmune Sera: Molecular Probes for the Identification of a Novel Autoantigen Kinase Signalling Pathway. J. Exp. Med. 2002. 196:1213-1226. PDF
Robinson WH, Garren H, Utz PJ, Steinman L. Millennium Award. Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease. Clin Immunol. 2002, 103(1):7-12. Review. PDF
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Robinson, W.H., Carla DiGennaro, Wolfgang Hueber, Brian B. Haab, Makoto Kamachi, Erik J. Dean, Sylvie Fournel, Derek Fong, Mark C. Genovese, Henry E. Neuman de Vegvar, Günter Steiner, David L. Hirschberg, Robert I. Morris, Sylviane Muller, Ger J. Pruijn, Walther J. van Venrooij, Josef S. Smolen, Patrick O. Brown, Lawrence Steinman and P.J. Utz. Autoantigen Microarrays for Multiplex Characterization of Autoantibody Responses. Nature Medicine. 2002. 8:295-301. PDF |
Zhang, C., Ao, Z, Utz, P.J., and Schlossman, S.F. Generation and characterization of monoclonal antibodies to autoantigen Ku70 by immunizing mice with apoptotic cells. Seventh Workshop and Conference on Human Leukocyte Differentiation Antigens. 2002. 524-526.
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Robinson, W., Steinman, L., and Utz, P.J. Review: Proteomics technologies to study autoimmune disease. Arthritis and Rheumatism. 2002. 46(4):885-93. PDF |
Utz, P.J. Report of the XXX EWRR, Vienna, Austria, March 2001. Arthritis Research. 2001. 3:237-240.
Gensler T., M. Hottelet, C. Zhang, S. Schlossman, P. Anderson and P.J. Utz. Monoclonal antibodies derived from Balb/c mice immunized with apoptotic Jurkat T cells recognize known autoantigens. J. Autoimm. 2001. 16:59-69.
Utz P.J., T.J. Gensler and P. Anderson. Review: Death, autoantigen modifications, and tolerance. Arth. Res. 2000. 2:101-114.
Overzet K., T.J. Gensler, M.E. Geiger, S.J. Kim, M. Hottelet, W.J. van Venrooij, K.M. Pollard, P. Anderson and P.J. Utz. Small nucleolar ribonucleoprotein (snoRNP) scleroderma autoantigens associate with phosphorylated serine arginine (SR) splicing factors during apoptosis. Arth. Rheum. 2000. 43:1327-1336. PDF
Utz, P.J. and P. Anderson. Review: Life and Death Decisions: Regulation of Apoptosis by Proteolysis of Signaling Molecules. Cell Death and Differentiation. 2000. 7:589-602. PDF
Degen, W.G.J., Y. van Aarssen, P. Piepers, G.J.M. Pruijn, P.J. Utz and W.J. van Venrooij. The fate of the U1 small nuclear RNP complex during anti-Fas induced apoptosis: specific cleavage of the U1 snRNA molecule. Cell Death and Differentiation. 2000. 7:70-80. PDF
Overzet, K., T.J. Gensler, M.E. Geiger, S.J. Kim, M. Hottelet, W. J. van Venrooij, K. M. Pollard, P. Anderson, and P.J. Utz. Small nucleolar ribonucleoprotein (snoRNP) scleroderma autoantigens associate with phosphorylated serine arginine (SR) splicing factors during apoptosis. Arthritis and Rheumatism. 2000. 43:1327-1336. PDF
Utz, P.J., T.J. Gensler, and P. Anderson. Review: Death, Autoantigen Modifications and Cell Tolerance. Arthritis Research. 2000. 2:101-114. PDF
Rutjes S.A., A. van der Heijden, P.J. Utz, W.J. van Venrooij, G.J Pruijn. Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis. Journal of Biological Chemistry. 1999. 274(35):24799-807. PDF
Rutjes, S.A., P.J. Utz, C. Broekhuis, A. van der Heijden, W.J. van Venrooij, and G.J.M. Pruijn. The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Cell Death and Differentiation. 1999. 6:976-986. PDF
Utz. P.J., M. Hottelet, W.J. van Venrooij, and P. Anderson. Association of phosphorylated serine/arginine (SR) splicing factors with the U1-snRNP autoantigen complex accompanies apoptotic cell death. Journal of Experimental Medicine. 1998. 187:547-560. PDF
Utz. P.J., M. Hottelet, S. Kim, M. Geiger, T. Le, W.J. vanVenrooij, and P. Anderson. The 72 kDa component of signal recognition particle (SRP) is cleaved during apoptosis. Journal of Biological Chemistry. 1998. 273:35299-35361. PDF
Utz. P.J. and P. Anderson. Review: Posttranslational Protein Modifications, Apoptosis, and the Bypass of Tolerance to Autoantigens. Arthritis and Rheumatism. 1998. 41:1152-1160. PDF
Utz. P.J., M. Hottelet, P.H. Schur, and P. Anderson. Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. Journal of Experimental Medicine. 1997. 185:843-854. PDF
Varon, J., J.R. Hamilton, J. Hostetler, P.J. Utz, and A. Ganer. Meningitis due to Group C streptococci. Hospital Physician. December 1991. 31-33.
Naumovski, L., P.J. Utz, S.K. Bergstrom, R. Morgan, A. Molina, J.J. Toole, B.E. Glader, P. McFall, L.M. Weiss, R. Warnke, and S.D. Smith. SUP-HD1: A new Hodgkin's Disease-derived cell line with lymphoid features produces interferon gamma. Blood. 1989. 74(8): 2733-2742. PDF
Sylvester, P.W., P.J. Utz, and M.M. Ip. Effects of the thiazolidinedione derivative CGP 19984 on growth and endocrine function of the MtTW10 transplantable mammosomatotropic pituitary tumor in the female rat. International Journal of Cancer. 1988. 42:289-294. PDF
Shaw, J.P., P.J. Utz, D.B. Durand, J.J. Toole, E.A. Emmel, and G.R. Crabtree. Identification of a putative regulator of early T-cell activation genes. Science. 1988. 241:202-205.
