The Utz Lab In The Department of Medicine


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Chakravarty, E.F., V. Martyanov, D. Fiorentino, T.A. Wood, D.J. Haddon, J.A. Jarrell, P.J. Utz, M.C. Genovese, M.L. Whitfield and L. Chung, 2015. Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis. Arthiritis Research and Therapy 17:159. PDF.

Haddon, D.J., V.K. Diep, J.V. Price, C. Limb, P.J. Utz and I. Balboni, 2015. Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus. Arth. Res. Ther. 17:162. PDF.

Haddon, D.J., J.A. Jarrell, M.R. Hughes, K. Snyder, K.M. McNagny, M.G. Kattah, and P.J. Utz, 2015. Measurement of Mast Cell Surface Molecules By High-Throughput Immunophenotyping Using Transcription (HIT). Methods in Molecular Biology. 1220:381-400. PDF.

Kattah, N.H., E.W. Newell, J.A. Jarrell, A,D. Chua, J. Xie, M.G. Kattah, O, Goldberger, J, Ye, E. F. Chakravarty, M.M. Davis, and P.J. Utz, 2015. Tetramers reveal IL-17–secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease. PNAS 112: 3044-3049. PDF.

Nguyen, L.X.T., Y. Lee, L. Urbani, P.J. Utz, A.W. Hamburger, J.B. Sunwoo, and B.S. Mitchell, 2015. Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1. Blood 125:2519-2529. PDF.

O’Gorman, W.E., E.W. Y. Hsieh, E.S. Savig, P.F. Gherardini, J.D. Hernandez, L. Hansmann, I.M. Balboni, P.J. Utz, S.C. Bendall, W.J. Fantl, D.B. Lewis, G.P. Nolan, and M.M. Davis, 2015. Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus. J. Allergy and Clinical Immunology. In Press. PDF.

Rasmussen, T.K., T. Andersen, R.O. Bak, G. Yiu, C.M. Sørensen, K. Stengaard-Pedersen, J.G. Mikkelsen, P.J. Utz, C.K. Holm and B. Deleuran, 2015. Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. Arthritis Research & Therapy 17: 154. PDF.

Rosenberg, J. and P.J. Utz, 2015. Protein arrays: a new tool for the study of autoantibodies in immunodeficiency. 2015. Frontiers in Immunology, 6:138. PDF.


Kinloch, A.J., A. Chang, K. Ko, C..J.H. Dunand, S. Henderson, D. Brandt, M. Maienschein-Cleine, N. Kaverina, B. Robin, M.S. Ferrer, D. Wlfgeher, V. Liarski, D.J. Haddon, P.J. Utz, P.C. Wilson and M.R. Clark, 2014. Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis. Arthritis and Rheumatol. 66:3359-3370. PDF.

Tang, X., B. Zhang, J.A. Jarrell, J.V. Price, H. Dai, P.J. Utz PJ and S. Strober, 2014. Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice. J. Autoimmunity. 50:87-98. PDF


Balboni, I., T.B. Niewold, G. Morgan, C. Limb, M.L. Eloranta, L. Rönnblom, P.J. Utz, L.M. Pachman, 2013, Interferon-α induction and detection of anti-ro, anti-la, anti-sm, and anti-rnp autoantibodies by autoantigen microarray analysis in juvenile dermatomyositis. Arthritis Rheum. 65:2424-9. PDF

Chruscinski, A.J., H. Singh, S.M. Chan and P.J. Utz, 2013. Broad-scale phosphoprotein profiling of beta adrenergic receptor (β-AR) signaling reveals novel phosphorylation and dephosphorylation events. PLoS One 5:e82164. PDF

Furman, D., V. Jojic, B. Kidd, S. Shen-Orr, J. Price, J. Jarrell, T. Tse, H. Huang, P. Lund, H.T. Maecker, P.J. Utz, C.L. Dekker, D. Koller and M.M. Davis, 2013. Apoptosis and other immune biomarkers predict influenza vaccine responsiveness. Mol Syst Biol. 9:659. PDF. Erratum in Mol Syst Biol. 2013;9:680.

Gottlieb, P., P.J. Utz, W. Robinso and L. Steinman, 2013. Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform. Clin Immunol. 149:297-306. PDF

Haddon, D.J., J.A. Jarrell, M.R. Hughes, K. Snyder, K.M. McNagny, M.G. Kattah, P.J. Utz, 2013. Book Chapter: Measurement of mast cell surface molecules using high-throughput immunophenotyping using transcription (HIT), in MAST Cells: Methods and Protocols. Humana Press..

Price, J.V., D.J. Haddon, D. Kemmer, G. Delepine, G. Mandelbaum , J.A. Jarrell, R. Gupta, I. Balboni, E.F. Chakravarty, J. Sokolove, A.K. Shum, M.S. Anderson, M.H. Cheng,W.H. Robinson, S.K. Browne, S.M. Holland, E.C. Baechler and P.J. Utz. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J. Clin. Invest. 123:5135-45. PDF

Price, J.V., J.A. Jarrell, D. Furman, N.H. Kattah, E. Newell, C.L. Dekker, M.N. Davis and P.J. Utz , 2013. Characterization of influenza vaccine immunogenicity using influenza antigen microarrays. PLoS One. 5:e64555. PDF

Roep, B.P., N. Solvason, P.A. Gottlieb, J.R. Abreu, L.C. Harrison, G.S. Eisenbarth, L.Yu, M. Leviten, W.A. Hagopian, J.B. Buse, M. von Herrath, J. Quan, R.S. King, W.H. Robinson, P.J. Utz, H. Garren, BHT-3021 Investigators and L. Steinman, 2013. Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8? T cells in type 1 diabetes. Sci Transl Med. 5:191ra82. PDF. Supplemental Material.

Zhang, B., J. Price, G. Hong, S.M. Tabakman, H. Wang, J.A. Jarrell, J. Feng, P.J. Utz and H. Dai, 2013. Multiplexed cytokine detection on plasmonic goldsubstrates with enhanced near-infrared fluorescence. Nano Research. PDF Epub ahead of publication

Zhang, B., J.A. Jarrell, J.V. Price, S.M. Tabakman, Y. Li, M. Gong, G. Hong, J. Feng, P.J. Utz and H. Dai, 2013. An integrated peptide-antigen microarray on plasmonic gold films for sensitive human antibody profiling. PLoS One 8:e71043. PDF


Junttila, I.S., R.J. Creusot, D.L. Bates, I. Moraga, P. Lupardus, P.J. Utz, C.G. Fathman, W.E. Paul, K.C. Garcia, 2012. Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines. Nature Chemical Biology. 8:990-998. (See News and Views Article) PDF

Landrigan, A., G. Yiu, K. Agarwal and P.J. Utz, 2012.Therapeutic Toll-like receptor agonists directly influence mouse and human T cell lymphoma cell viability and cytokine secretion. Leukemia & Lymphoma. 54:166-168. PDF

Lin, J.T., E.A. Stein, M.T. Wong, K.J. Kalpathy L.L. Su, P.J. Utz, W.H. Robinson and C.G. Fathman, 2012. Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis. Clinical Immunology. 142(2):127-38. PDF

Liu, C.L.L., S. Tangsombatvisit, J.M. Rosenberg, G. Mandelbaum, E.C. Gillespie, O.P. Gozani, A.A. Alizadeh and P.J. Uz, 2012. Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies. Arthritis Research & Therapy, 14:R25. PDF Correction

Maecker, H.T., T.M. Lindstrom, W.H. Robinson, P.J. Utz, M. Hale, S.D. Boyd, S.S. Shen-Orr, and C.G. Fathman, 2012. New tools for the classification and monitoring of autoimmune diseases. Nat. Rev. Rheumatol. 8:317-328. PDF

Price, J.V., S. Tangsombatvisit, G. Xu, J. Yu, D. Levy, E.C. Baechler, O. Gonzani, M. Varma, P.J. Utz and C.L. Liu, 2012. On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions. Nature Medicine. PDF

Teo, P.Z., P.J. Utz, J.A. Mollick, 2012. Using the allergic immune system to target cancer: activity of IgE antibodies specific for human CD20 and MUC1. Cancer Immunol Immunother. 2012 Jun 13. PDF


Alonso, M.N., M.T. Wong, A.L. Zhang, D. Winer, M.M. Suhoski, L.L. Tolentino, J. Gaitan, M.G. Davidson, T.H. Kung, D.M. Galel, K.C. Nadeau, J. Kim, P.J. Utz, K. Söderström and E.E. Engleman, 2011. TH1, TH2 and TH17 cells instruct monocytes to differentiate into specialized dendritic cell subsets. Blood. 118:3311-3320. PDF

Cheung, R.K., and P.J. Utz, 2011. Screening: CyTOF-the next generation of cell detection. Nat. Rev. Rheumatol. 7:502-503. PDF

Landrigan, A., M.T. Wong and P.J. Utz, 2011. CpG- and non-CpG oligodeoxynucleotides directly activate T cells through a TLR9- and MyD88-independent mechanism. J. Immunol., Aug. 15, 2011. PDF

Levy, D., C.L.L. Chin, Z. Yang, A. M. Newman, A.A. Alizadeh, P.J .Utz and O. Gozani, 2011. A proteomic approach for the identification of novel lysine methyltransferase substrates. Epigenetics & Chromatin 4:19-30. PDF

Levy, D., A.J. Kuo, Y. Chang, U. Schaefer, C. Kitson, P. Cheung, A. Espejo, B.M. Zee, C.L. Liu, S. Tangsombatvisit, R.I. Tennen, A.Y. Kuo, S. Tanjing, R. Cheung, K.F. Chua, P.J. Utz, X. Shi, R.K. Prinjha, K. Lee, B.A. Garcia, M.T. Bedford, A. Tarakhovsky, X. Cheng and O. Gozani, 2011. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nature Immunology. 12:29-36. PDF

Qin, H, I.-F. Lee, C. Panagiotopoulos, X. Wang, A.D. Chu, P.J. Utz, J.J. Priatel and R. Tan, 2011. Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling. Diabetes 60:857-866. PDF

Singh, H., K.A. Henry, S.S.T. Wu, A. Chruscinski, P.J. Utz and J.K. Scott, 2011. Reactivity profiles of broadly neutralizing anti-HIV-1 antibodies are distinct from those of pathogenic autoantibodies. AIDS, 25:1247-1346. PDF

Tabakman, S.D., L. Lau, J.T. Robinson, J. Price, S.P. Sherlock, H. Wang, B. Zhang, Z. Chen, S. Tangsombatvisit, J.A. Jarrell, P.J. Utz and H. Dai, 2011. Plasmonic substrates for multiplexed protein microarrays with femtomolar sensitivity and broad dynamic range. Nature Commications. 2: Article Number 466. PDF

Woo, S.R., M.E. Turnis, M.V. Goldberg, J. Bankoti, M. Selby, C.J. Nirschl, M.L. Bettini, D.M. Gravano, P. Vogel, C.L. Liu, S. Tangsombatvisit, J.F. Grosso, G. Netto, M.P. Smeltzer, A. Chaux, P.J. Utz, C.J. Workman, D.M. Pardoll, A.J. Korman, C.G. Drake and D.A. Vignali, 2012. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res 72:917-927. PDF


Graham, K., L. Lee, J. Higgins, P.J. Utz, L. Steinman and P. Ho, 2010. Treatment with a toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice. Autoimmunity 43:140-155. PDF

Kattah, N.H., M.G. Kattah, P.J. Utz, 2010. The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases. Immunol. Rev. 233:126-145. PDF

Richez, C., K. Yasuda, R.G. Bonegio, AA.Watkins, T. Aprahamian, P. Busto, R.J. Richard, C.L. Liu, R. Cheung, P.J. Utz, A. Marshak-Rothstein and I.R. Rifkin, 2010. IFN regulatory factor 5 is required for disease development in the FcγRllB-/-Yaa and FcγRllB-/- mouse models of systemic lupus erythematosus. J. Immunol.184:796-806. PDF

Tavares, R.M., E.E. Turer, C.L. Liu, R. Advincula, P. Scapini, L. Rhee, J. Barrera, ClA. Lowell, P.J. Utz, B.A. Malynn and A. Ma, 2010. The Ubiquitin Modifying Enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity, 33:181-191. PDF

Wong, M., J. Ye, E.E. Engleman and P.J. Utz, 2010. Regulation of human Th9 differentiation by type I interferons and IL-21. Immunology and Cell Biology. 88:624-632. PDF


Lin, J.T., N.B. Lineberry, M.G. Kattah, L.L. Su, P.J. Utz, C.G. Fathman, L. Wu, 2009. Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAILexpression. J Immunol. 182:5919-5928. PDF

Thibault, D.L. K.L. Graham, L.V. Lee, I. Balboni, P.J. Hertzog and P.J. Utz, 2009. Type I IFN receptor controls B cell expression of nucleic acid sensing toll-like receptors and autoantibody production in a murine model of lupus. Arthritis Res Ther. 11:R112. PDF

Wu,, J.C., A. Chruscinski, V.A. De Jesus Perez, H. Singh, M. Pitsiouni, M. Rabinovitch, P.J. Utz and J.P. Cooke, 2009. Cholinergic modulation of angiogenesis: Role of the 7 nicotinic acetylcholine receptor. J Cell Biochem. 2009 Jul 21. PDF


Balboni, I., C. Limb, J.D. Tenenbaum, P.J. Utz, 2008. Evaluation of microarray surfaces and arraying parameters for autoantibody profiling. Proteomics. 8:3443-3449. PDF

Chen, Z., S.M. Tabakman, A.P. Goodwin, M.G. Kattah, D. Daranciang, X. Wang, G., Zhang, X. Li, Z. Liu, P.J. Utz, K. Jiang, S. Fan and H. Dai, 2008. Protein microarrays with carbon nanotubes as multicolor Raman labels. Nat. Biotechnology. 26:1285-92. Epub 2008 Oct. 26. PDF

Drouvalakis, K.A., S. Bangsaruntip, W. Hueber, L.G. Kozar, P.J. Utz, H. Dai, 2008. Peptide-coated nanotube-based biosensor for the detection of disease-specific autoantibodies in human serum. Biosensors and Bioelectronics. 23:1413-1421. PDF

Garren, H., W.H. Robinson, E. Krasulova´, E Havrdova´, C. Nadj, K. Selmaj, J. Losy, I. Nadj, E.-W. Radue, B.A. Kidd, J. Gianettoni, K. Tersini, P.J. Utz, F. Valone, L. Steinman, and the BHT-3009 Study Group, 2008. Phase 2 Trial of a DNA Vaccine Encoding Myelin Basic Protein for Multiple Sclerosis. Ann. Neurol. 63:611-620. PDF

Graham, K.L., L.Y. Lee, J.P. Higgins, L. Steinman L, P.J. Utz and P.P. Ho, 2008. Failure of oral atorvastatin to modulate murine model of systemic lupus erythematosus. Arthritis Rheum. 58:2098- 2104. PDF.

Holst J., H. Wang, K.D. Eder, C.J. Workman, K.L. Boyd, Z. Baquet, H. Singh, K. Forbes, A. Chruscinski, R. Smeyne, N.S. van Oers, P.J. Utz, D.A. Vignali, 2008. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimunity. Nature Immunology. 9:658-666. PDF

Kattah, M.G., J. Coller, R.K. Cheung, N. Oshidary, P.J. Utz PJ., 2008. HIT: a versatile proteomics platform for multianalyte phenotyping of cytokines, intracellular proteins and surface molecules. Nat Med. 14:1284-1289. Epub 2008 Oct 12. PDF

Kattah, MG, MT Wong, MD Yocum, PJ Utz, 2008. Cytokines secreted in response toTLF-ligand stimulation modulate IL-1induced TH-17 differentiation. Arthritis Rheum. 58:1619-1629. PDF

Kattah, MG, PJ Utz, I Balboni. Editorial: Protein microarrays address the elephant in the room. Clin Chem. 54:937-939. PDF

Li, D.H., M.M. Winslow, T.M. Cao, A.H. Chen, C.R. Davis, E.D. Mellins, P.J. Utz, G.R. Crabtree, J.R. Parnes. 2008. Arthritis Rheum. 58:1285-1292. PDF

Tenenbaum, J.D., M.G. Walker1, P.J. Utz and A.J. Butte, 2008. Expression-based Pathway Signature Analysis (EPSA): Mining publicly available microarray data for insight into human disease. BMC Med. Genomics. 1:51-62. PDF

Thibault, D.L., A.D. Chu, K. L. Graham, I. Balboni, L.Y. Lee, C. Kohlmoos, A, Landrigan, J.P. Higgins, R. Tibshirani, and P.J. Utz, 2008. IFR9 and STAT1 are require for IgG autoantibody production and B-cell expression of TLR7 in mice. J. Clin. Invest.118:1417-26. PDF


Bar-Or, A., Vollmer, T., Antel, J., Arnold, D.L., Bodner, C.A., Campagnolo, D., Gianettoni, J., Jalili, F.,Kachuck, N., Lapierre, Y., Niino, M., Oger, J., Price, M., Rhodes, S., Robinson, W.H., Shi, F.-D., Utz, P.J., Valone, F., Weiner, L., Steinman, L., Garren, H. Induction of Antigen-Specific Tolerance in Multiple Sclerosis After Immunization With DNA Encoding Myelin Basic Protein in a Randomized, Placebo-Controlled Phase 1/2 Trial. Arch. Neurol. 2007;64:E1-E9. PDF.

Chan, S.M., A.P. Weng, R. Tibshirani, J.C. Aster and P.J. Utz, 2007. Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood. 110:278-286. PDF

Matthews, A.G., A.J. Kuo, S. Ramón-Maiques, S. Han, K.S. Champagne, D. Ivanov, M. Gallardo, D. Carney, P. Cheung, D.N. Cicone, K.L. Walkter, P.J. Utz, Y. Shi, T.G. Kutateladzem, W. Yang, O. Gozani and M.A. Oettinger, 2007. RAG2 PHD finger couples histone He lysine 4 trimethylation with V(D)J recomb ination. Nature. 450:1106-1110. PDF

Pennathur S., F. Baldessari, M.G. Kattah, P.J. Utz and J.G. Santiago, 2007. Free-solution oliogonucleotide seperation in nanoscale channels. Anal. Chem. 79:8316-8322. PDF

Sharpe, V. and P.J. Utz, 2007. Technology Insight: can autoantibody profiling improve clinical practice? Nature Clinical Practice. 3:96-103. PDF

Shi, X., I. Kachirskaia, K.L. Walker, J.H. Kuo, A. Lake, F. Favrazou, S.M. Chan, D.G. Martin, I.M. Fingerman, S.D. Briggs, L. Howe, P.J. Utz, T.G. Kutateladze, A.A. Lugovskoy, M.T. Bedford, O. Gozani, 2007. Proteome-wide analysis in Sacchromyces cerevisiae identifies several PHD fingers as novel direct and selective modules of histone H3 methylated at either lysine 4 or lysine 36. Journl of Biological Chemistry. 282:2450-55. PDF


Balboni I., S.M. Chan, M. Kattah, J.D. Tenenbaum, A.J. Butte and P.J. Utz. Multiplexed protein array platforms for analysis of autoimmune diseases. In: Annual Review of Immunology, W. Paul, C.G. Fathman, L.H. Glimcher (Eds), pps. 391-418, Vol. 24, 2006. PDF

Chan SM, J. Olsen, P.J. Utz. Single-cell analysis of siRNA-mediated gene silencing using multiparameter flow cytometry. Cytometry. 2006. 69A(2):59-65. PDF

Graham, K.L., M. Vaysberg, A. Kuo and P. J. Utz, 2006. Autoantigen arrays for multiplex analysis of antibody isotypes. Proteomics 2006, 6:5720–5724. PDF

Kattah M.G., G.R. Alemi, D.L. Thibault and P.J. Utz. A novel two-color fab labeling method for autoantigen protein microarrays. Nature Methods. 2006.3:745-751. PDF

Paniagua RT, P Sharpe, PP Ho, SM Chan, A Chang, JP Higgins, BH Tomooka, FM Thomas, JJ Song, SB Goodman, MC Genovese, PJ Utz, L STeinman, WR Robinson, 2006. Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of rheumatoid arthritis. J. Clin. Invest. 115:2633-2642. PDF

Sekine H., K. L. Graham, S. Zhao, M.K. Elliott, P. Ruiz, L. Morel, V. M. Holers, P.J. Utz and G. S. Gilkeson. Role of MHC-linked genes in autoantigen selection and renal disease in a murine model of SLE. J. Immunol. 2006. 177:7423-7434. PDF


Chan S.M. and P.J. Utz, 2005. The challenge of analyzing the proteome in humans with autoimmune diseases. Ann. NY Acad. Sci. 1062:61-68. PDF

Fathman, C.G., L. Soares, S.M. Chan and P.J. Utz., 2005. An array of possibilities for the study of autoimmunity. Nature 435:605-611. PDF

Graham K.L., D. L. Thibault, M. Kamachi, S. Zhao, J. Steinman, L. Okeke, P. N. Kao and P.J. Utz., 2005. Granzyme B is dispensable for immunological tolerance to self in a murine model of systemic lupus erythematosus. Arth. Rheum. 52:1684-1693. PDF

Graham K.L. and P.J. Utz, 2005. Sources of autoantigens in systemtic lupus erythematosus. Curr. Opin. Rheumatol. 17:513-517. PDF

Huang, M., H. Ida, M. Kamachi, N. Iwanaga, Y. Izumi, F. Tanaka, K. Aratake, K. Arima, M. Tamai, A. Hida, H. Nakamura, T. Origuchi, A. Kawakami, N. Ogawa, S. Sugai, P.J. Utz and K. Eguchi, 2005. Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren’s Syndrome. Clin. Exp. Immunol. 42:148-154. PDF

Hueber W., B.A. Kidd, B.H. Tomooka, B.J. Lee, B. Bruce, J.L. Fries, G. Sonderstrup, P. Monach, J.W. Drijfhout, W.J. van Venrooij, P.J. Utz, M.C. Genovese and W.H. Robinson, 2005. Antigen microarray profiling of autoantibodies in rheumatoid arthritis. Arthritis Rheum. 52:2645-55. PDF

Huston D.P., C.G. Fathman and P.J. Utz, 2005. Fostering interdisciplinary immunology. Clin. Immunol. 115:1-2. PDF

Ida I., P.J. Utz, P. Anderson and K. Eguchi, 2005. Granzyme B and natural killer (NK) death. Mod. Rheumtol. 2005. 15:315-322. PDF

Steinman L., P.J.Utz and W.H. Robinson, 2005. Suppression of autoimmunity via microbial mimics of altered peptide ligands. Curr Top Microbiol Immunol. 296:55-63. PDF

Utz, P.J., 2005. Protein arrays for studying blood cells and their secreted products. Immunol. Rev. 2005. 204:264-282. PDF


Chan, S.M., J. Ermann, L. SU, C.G. Fathman and P.J. Utz, 2004. Protein Microarrays for Multiplex Analysis of Signal Transdaucton Pathways. Nature Medicine. 10:1390-1396. Supporting Documents: Raw Data (Excel Format), Antibody Sources (Excel), Lysis Buffer Recipe (Word Format), Reverse Phase Microarray Protocol (Word Format). PDF

Chung L. and P.J. Utz, 2004. Autoantibodies in scleroderma: Direct pathogenicity and phenotypic associations. Curr. Rheum. Reports 2004. 6:156-163. PDF

Graham, K.L., K.E. Gustin, C. Rivera, N.M. Kuyumcu-Martinez, S.S. Choe, R.E. Lloyd P. Sarnow and P.J. Utz, 2004. Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection. J. Virol. 78:6313-21. PDF

Graham K.L., W.H. Robinson, L. Steinman and P.J. Utz, 2004. High-throughput methods for measuring autoantibodies in systemic lupus erythematosus and other autoimmune diseases. Autoimmunity. 37:269-72. Review. PDF

Hueber, W. and Utz, P.J. "Modifications of RNA During Apoptosis." In, Apoptosis and Autoimmunity, Edited by Joachim Kalden and Martin Herrmann. 2003. 299-315.

Hueber, W., D. Zeng, O. Sharpe, W.H. Robinson, S. Strober and P.J. Utz, 2004. Characterization of novel antigens recognized by serum autoantibodies from anti-CD1 TCR-transgenic lupus mice. Eur. J. Immunol. 34:1654–1662. PDF

Hueber, W., D. Zeng, S. Strober and P.J. Utz, 2004. Interferon-alpha-inducaible proteins are novel antigens in murine lupus. Arthritis and Rheumitism. 50:3239-3249. PDF

Su, L., R.J. Creusot, E.Gallo, S.M. Chan, P.J. Utz, C.G. Fathman and J. Ermann, 2004. Murine CD4+CD25+-regulatory T-cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene. J. Immuol. 173:4994-5001. PDF

Utz P.J., 2004. Hot technologies in immunology. Clin. Immunol. 111:153-4. PDF

Utz, P.J., 2004. Multiplexed assays for identification of biomarkers and surrogate markers in systemic lupus erythematosus. Lupus. 13:304-11. PDF

Utz., P.J. and S. Chan, 2004. Autoantibodies profiling and lymphocyte characterization using autoantigen and lysate arrays. In Pathogenic and Diagnostic Relevance of Autoantibodies. K. Conrad, R. L. Humbel, M. Meurer, Y. Shoenfeld, E.M. Trans (Eds.) 7th Dresden, Sept. 1-4, 2004.

Utz P.J., M.C. Genovese and W.H. Robinson, 2004.Unlocking the "PAD" lock on rheumatoid arthritis. Ann. Rheum. Dis. 4:330-332. PDF

Utz P.J., L. Steinman and W.H. Robinson, 2004. Protein microarrays for analysis of immune responses in animals and humans. In: Protein Micoarrays, pp 365-376, Edited by Michael Schena. Jones and Bartlett, Sudbury, MA.


Chen, R.J., S. Bangsaruntip, K. A. Drouvalakis, N.W.S. Kam, M. Shim, Y. Li, W. Kim, P.J. Utz and H. Dai, 2003. Noncovalent functionalization of carbon nanotubes for highly specific electronic sensors. Proc. Natl. Acad. Sci. USA 100:4984-4989. PDF

Herr, A.E., J.I. Molho, K.A. Drouvalakis, J.C. Mikkelsen, P.J. Utz, J.G. Santiago and T.W. Kenny, 2003. On-Chip Coupling of Isoelectric Focusing and Free Solution Electrophoresis for Multi-Dimensional Separations. Anal. Chem. 75:1180-1187. PDF

Hueber, W. and .J. Utz, 2003. Modifications of RNA during apoptosis. In: Apoptosis and Autoimmunity, pps. 299-315. Edited by Joachim Kalden and Martin Herrmann.

Hueber W., P.J. Utz and W.H, Robinson, 2003. Autoantibodies in early arthritis: advances in diagnosis and prognostication. Clin Exp Rheumatol. 21(5 Suppl 21): S59-64. Review. PDF

Neuman de Vegvar, H.E., R.R. Amara, L. Steinman, P.J. Utz, H.L. Robinson and W.H. Robinson, 2003. Microarray profiling of antibody responses against Simian-Human immunodeficiency virus: Postchallenge of host histocompatibility type and vaccine regimen. J. Virol. 77:11125-11138. PDF

Robinson, W.H., P. Fontoura, B.J. Lee, H.E. Neuman de Vegvar, J. Tom, R. Pedotti, C.D. DiGennaro, D.J. Mitchell, D. Fong, P.P-K. Ho, P. Ruiz, E. Maverakis, D.B. Stevens, C.C.A. bernard, R. Martin, V.K. Kuchroo, J.M. van Noort, C.P. Genain, S. Amor, T. Olsson, P.J. Utz*, H. Garren* and L. Steinman*, 2003. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nature Biotechnol. 21:1033-1039. *All three authors contributed equally to this paper. PDF.

Robinson, W.H., L. Steinman, and P.J. Utz, 2003. Protein arrays for autoantibody profiling and fine-specificity mapping. Proteomics, 3:2077-84. PDF

Robinson, W.H., P.J. Utz, and L. Steinman, 2003. Genomic and proteomic analysis of multiple sclerosis. Opinion. Curr Opin Immunol. 15:660-7. PDF

Thibault, D.L and P.J. Utz, 2003. Interpreting interest in interferon-alpha. Arthritis Res. and Res. Ther. 5(5):246-248. PDF


Hueber W., P.J. Utz, L. Steinman and W.H,Robinson, 2002. Autoantibody profiling for the study and treatment of autoimmune disease. Arthritis Res. 4(5):290-5. Review. PDF

Kamachi M. T.M. Le, S. Kim, M.E. Geiger, P. Anderson and P.J. Utz, 2002. Human Autoimmune Sera: Molecular Probes for the Identification of a Novel Autoantigen Kinase Signalling Pathway. J. Exp. Med. 196:1213-1226. PDF

Robinson, W.H., C.DiGennaro, W. Hueber, B.B. Haab, M. Kamachi, E.J. Dean, S. Fournel, D. Fong, M.C. Genovese, H.E. Neuman de Vegvar, G. Steiner, D.L. Hirschberg, R.I. Morris, S. Muller, G.J. Pruijn, W.J. van Venrooij, J.S. Smolen, P.O. Brown, L. Steinman and P.J. Utz, 2002. Autoantigen Microarrays for Multiplex Characterization of Autoantibody Responses. Nature Biotechnology. 8:295-301. PDF


Robinson W.H., H. Garren, P.J. Utz and L. Steinman, 2002. Millennium Award. Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease. Clin Immunol. 103(1):7-12. Review. PDF

Robinson W.H., L. Steinman and P.J. Utz, 2002. Protein and peptide array analysis of autoimmune disease. Biotechniques. Suppl:66-9. Review. PDF

Robinson, W., L. Steinman, and P.J. Utz, 2002. Review: Proteomics technologies to study autoimmune disease. Arthritis and Rheumatism. 46(4):885-93. PDF

Zhang, C., Z. Ao, P.J. Utz, and S.F. Schlossman, 2002. Generation and characterization of monoclonal antibodies to autoantigen Ku70 by immunizing mice with apoptotic cells. Seventh Workshop and Conference on Human Leukocyte Differentiation Antigens. 2002. 524-526.


Gensler T., M. Hottelet, C. Zhang, S. Schlossman, P. Anderson and P.J. Utz, 2001. Monoclonal antibodies derived from Balb/c mice immunized with apoptotic Jurkat T cells recognize known autoantigens. J. Autoimm. 16:59-69. PDF

Utz, P.J., 2001. Report of the XXX EWRR, Vienna, Austria, March 2001. Arthritis Research.3:237-240. PDF


Degen, W.G.J., Y. van Aarssen, P. Piepers, G.J.M. Pruijn, P.J. Utz and W.J. van Venrooij, 2000. The fate of the U1 small nuclear RNP complex during anti-Fas induced apoptosis: specific cleavage of the U1 snRNA molecule. Cell Death and Differentiation. 7:70-80. PDF

Overzet K., T.J. Gensler, M.E. Geiger, S.J. Kim, M. Hottelet, W.J. van Venrooij, K.M. Pollard, P. Anderson and P.J. Utz, 2000. Small nucleolar ribonucleoprotein (snoRNP) scleroderma autoantigens associate with phosphorylated serine arginine (SR) splicing factors during apoptosis. Arth. Rheum. 43:1327-1336. PDF

Utz, P.J. and P. Anderson, 2000. Review: Life and Death Decisions: Regulation of Apoptosis by Proteolysis of Signaling Molecules. Cell Death and Differentiation. 7:589-602. PDF

Utz P.J., T.J. Gensler and P. Anderson, 2000. Review: Death, autoantigen modifications, and tolerance. Arth. Res. 2:101-114. PDF


Rutjes S.A., A. van der Heijden, P.J. Utz, W.J. van Venrooij and G.J Pruijn, 1999. Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis. Journal of Biological Chemistry. 1999. 274(35):24799-807. PDF

Rutjes, S.A., P.J. Utz, C. Broekhuis, A. van der Heijden, W.J. van Venrooij, and G.J.M. Pruijn, 1999. The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Cell Death and Differentiation. 6:976-986. PDF


Utz. P.J. and P. Anderson, 1998. Review: Posttranslational Protein Modifications, Apoptosis, and the Bypass of Tolerance to Autoantigens. Arthritis and Rheumatism. 41:1152-1160. PDF

Utz. P.J., M. Hottelet, S. Kim, M. Geiger, T. Le, W.J. vanVenrooij and P. Anderson, 1998. The 72 kDa component of signal recognition particle (SRP) is cleaved during apoptosis. Journal of Biological Chemistry. 273:35299-35361. PDF

Utz. P.J., M. Hottelet, W.J. van Venrooij and P. Anderson, 1998. Association of phosphorylated serine/arginine (SR) splicing factors with the U1-snRNP autoantigen complex accompanies apoptotic cell death. Journal of Experimental Medicine. 187:547-560. PDF


Utz. P.J., M. Hottelet, P.H. Schur and P. Anderson, 1997. Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. Journal of Experimental Medicine. 185:843-854. PDF


Varon, J., J.R. Hamilton, J. Hostetler, P.J. Utz and A. Ganer, 1991. Meningitis due to Group C streptococci. Hospital Physician. December 31-33.


Naumovski, L., P.J. Utz, S.K. Bergstrom, R. Morgan, A. Molina, J.J. Toole, B.E. Glader, P. McFall, L.M. Weiss, R. Warnke, and S.D. Smith, 1989. SUP-HD1: A new Hodgkin's Disease-derived cell line with lymphoid features produces interferon gamma. Blood. 74(8): 2733-2742. PDF


Shaw, J.P., P.J. Utz, D.B. Durand, J.J. Toole, E.A. Emmel, and G.R. Crabtree. Identification of a putative regulator of early T-cell activation genes. Science. 1988. 241:202-205. PDF

Sylvester, P.W., P.J. Utz, and M.M. Ip, 1988. . Effects of the thiazolidinedione derivative CGP 19984 on growth and endocrine function of the MtTW10 transplantable mammosomatotropic pituitary tumor in the female rat. International Journal of Cancer. 1988. 42:289-294. PDF

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